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Updated: Jul 14, 2026

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis
Published on: May 23, 2025
[Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension]
Xu Dong1, Gang Wang, Huai-liang Wang
1Department of Biochemistry, Dalian Medical University, Dalian 116027, China. dongxu-73@sohu.com
Objective:
To observe the changes in pulmonary artery protein kinase C (PKC) activity in rats with chronic inflammatory pulmonary hypertension (PHT).
Methods:
Chronic inflammatory PHT was induced in rats with monocrotaline. The PKC activities in the rat pulmonary arteries were measured by radioactive assay during the development of PHT.
Results:
With the development of chronic inflammatory PHT, the total and cytosolic fractions of PKC activity in PHT rat pulmonary arteries increased initially with subsequent decrease (Plt;0.05), but the membranous fraction of PKC activity and the membrane-to-cytosol PKC activity ratio increased continuously (P<0.05).
Conclusion:
The up-regulation of PKC activity and the translocation of PKC might be associated with the development of chronic inflammatory PHT in rats.
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