Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulse amplitude adjustment provides immediate pacemaker longevity gain.

Nenad Zlatanovic1, Sasko Kedev, Nikola Gjorgov

  • 1Institute for Heart Diseases, University Clinical Center, Skopje, Republic of Macedonia. zlic2009@ukim.edu.mk

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|August 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breaking The Stone: Stentless Coronary Revascularization with Intravascular Lithotripsy and Drug-Coated Balloon Technology Guided by IVI.

Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)·2026
Same author

Standard modifiable cardiovascular risk factors and acute coronary syndrome free survival.

Atherosclerosis·2026
Same author

The paradox of SMURF-less outcomes and its implication for diabetes.

European heart journal. Quality of care & clinical outcomes·2026
Same author

Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca<sup>2+</sup> microdomains to initiate T cell activation.

Science signaling·2026
Same author

Abluminus DES+ sirolimus-eluting stent versus everolimus-eluting stent in patients with diabetes and coronary artery disease (ABILITY Diabetes Global): results from a multicentre, randomised controlled trial.

Lancet (London, England)·2026
Same author

Late Thrombosis of First-Generation Bioresorbable Scaffold Site Treated With Novel Resorbable Magnesium Scaffold.

JACC. Case reports·2025

Reducing pacemaker pulse amplitude by 1 V significantly extends pacemaker longevity by over a year. This adjustment lowers battery current, offering a substantial initial gain in device lifespan.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Pacemaker longevity is crucial for patient care and device management.
  • Optimizing pacemaker settings can potentially extend device operational life.
  • Factory settings may not represent the most energy-efficient configuration for all pacemakers.

Purpose of the Study:

  • To determine the initial longevity gain achievable by adjusting pacemaker pulse amplitude.
  • To investigate the impact of reduced pulse amplitude on pacemaker battery current and projected lifespan.

Main Methods:

  • Analyzed 40 patients with pacemakers operating at factory settings (3.5 V, 0.4 ms).
  • Performed pulse amplitude threshold tests.
  • Programmed pacemakers to a lower pulse amplitude (2.5 V) while keeping pulse width constant.

Related Experiment Videos

  • Monitored battery voltage and current, and projected longevity.

    • Main Results:

    • Decreasing pulse amplitude to 2.5 V reduced battery current from 14.21 microA to 11.53 microA.
    • Projected pacemaker longevity increased by an average of 12.42 months (p=0.003).
    • A positive correlation was observed between lower pulse amplitude and reduced battery current (p<0.01).

    Conclusions:

    • A modest reduction in pacemaker pulse amplitude (1 V) yields a significant initial increase in device longevity exceeding one year.
    • Further research is needed to ascertain the long-term impact of these correlations on overall pacemaker lifespan.