Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PIC: Protein Interactions Calculator.

K G Tina1, R Bhadra, N Srinivasan

  • 1Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

Nucleic Acids Research
|June 23, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis, crystal structure and Hirshfeld surface analysis of bis-[<i>N</i>-(4-chloro-benz-yl)-<i>N</i>-do-decyl-dithio-carbamato-κ<sup>2</sup> <i>S</i>,<i>S</i>']palladium(II).

Acta crystallographica. Section E, Crystallographic communications·2026
Same author

Comment on "efficacy of glucagon-like Peptide-1 receptor agonists in idiopathic intracranial hypertension: A systematic review and meta-analysis".

Journal of the neurological sciences·2026
Same author

Deciphering the role of Saliva in COVID 19: A global cross-sectional study on the knowledge, awareness and perception among dentists.

BMC oral health·2023
Same author

Decreased Brain Ventricular Volume in Psychiatric Inpatients with Serotonin Reuptake Inhibitor Treatment.

Chronic stress (Thousand Oaks, Calif.)·2022
Same author

Efficient catalytic activity of BiVO<sub>4</sub> nanostructures by crystal facet regulation for environmental remediation.

Chemosphere·2021
Same author

Enhanced photocatalytic and photodynamic activity of chitosan and garlic loaded CdO-TiO<sub>2</sub> hybrid bionanomaterials.

Scientific reports·2021

The Protein Interactions Calculator (PIC) identifies crucial protein interactions, including hydrogen bonds and hydrophobic interactions, essential for understanding protein stability and function. This tool aids in visualizing these molecular interactions within protein structures and complexes.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Protein structure and interactions are fundamental to molecular stability and function.
  • Understanding inter-residue interactions is key to deciphering protein behavior.
  • Various weak and strong forces contribute to protein structural integrity.

Purpose of the Study:

  • To introduce the Protein Interactions Calculator (PIC) server for analyzing protein interactions.
  • To provide a comprehensive tool for identifying diverse types of molecular interactions within proteins and complexes.
  • To facilitate the visualization and analysis of residue-level interactions.

Main Methods:

  • Utilizes 3D coordinate sets of protein structures.
  • Computes various interactions: disulfide bonds, hydrophobic, ionic, hydrogen bonds, aromatic-aromatic, aromatic-sulfur, and cation-pi.

Related Experiment Videos

  • Calculations based on standard, published criteria.

    • Main Results:

    • PIC server identifies and quantifies multiple types of inter-residue interactions.
    • Provides accessible surface area and residue-depth information.
    • Enables visualization of interactions using RasMol and Jmol interfaces.

    Conclusions:

    • PIC offers a centralized platform for comprehensive protein interaction analysis.
    • Facilitates detailed study of interactions involving buried or exposed residues.
    • Enhances understanding of protein stability and function through detailed interaction mapping.