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Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and

Christian Danielsson1, Faranak Azarbayjani, Anna-Carin Sköld

  • 1Department of Medicine, Karolinska Institute, Karolinska University Hospital, S 14186 Stockholm, Sweden.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|June 23, 2007
PubMed
Abstract

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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