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Updated: Jul 14, 2026
10:24
Quantitation of Endothelial Cell Adhesiveness In Vitro
Published on: June 18, 2015
Endothelial signaling by Ig-like cell adhesion molecules
Jaap D van Buul1, Edwin Kanters, Peter L Hordijk
1Department of Molecular Cell Biology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.
Arteriosclerosis, Thrombosis, and Vascular Biology
|June 23, 2007
Summary
Leukocyte migration across blood vessels involves endothelial cell adhesion molecules (IgCAMs). These molecules initiate signaling cascades, influencing cytoskeletal changes and cell-cell contact, crucial for immune cell movement.
Area of Science:
- Immunology
- Cell Biology
- Vascular Biology
Background:
- Leukocyte migration is essential for immune response.
- Endothelial cell adhesion molecules (IgCAMs) mediate leukocyte adhesion and transmigration.
- Intercellular adhesion molecule-1 (ICAM-1) is a key IgCAM involved in these processes.
Purpose of the Study:
- To review recent insights into IgCAM-driven signaling in endothelial cells.
- To elucidate the role of IgCAM clustering in leukocyte transendothelial migration.
Main Methods:
- Literature review of studies on leukocyte migration and endothelial cell signaling.
- Analysis of signaling pathways initiated by IgCAM clustering.
- Examination of cytoskeletal dynamics and cell-cell contact modulation.
Main Results:
- IgCAM clustering triggers intracellular signaling events in endothelial cells.
- Activation of Rho-like GTPases and cytoskeletal rearrangements are key consequences.
- Transient modulation of endothelial cell-cell contacts facilitates leukocyte passage.
Conclusions:
- IgCAMs are critical regulators of leukocyte transendothelial migration.
- Understanding IgCAM-driven signaling provides insights into immune cell trafficking.
- Targeting these pathways may offer therapeutic strategies for inflammatory diseases.
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