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Related Experiment Videos

Epigenetic landscape required for placental development.

M Hemberger1

  • 1The Babraham Institute, Babraham Research Campus, Cambridge, CB223AT, United Kingdom. myriam.hemberger@bbsrc.ac.uk

Cellular and Molecular Life Sciences : CMLS
|June 23, 2007
PubMed
Summary
This summary is machine-generated.

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Genetic and genomic approaches to study placental development.

Cytogenetic and genome research·2004

Epigenetic instructions guide extraembryonic cell differentiation and placental formation. Key epigenetic mechanisms, like imprinted gene expression, are crucial for mammalian embryo development and survival.

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Genetics

Background:

  • Extraembryonic tissues, especially the placenta, are vital for mammalian embryonic development.
  • Gene expression during development relies on epigenetic instructions for cell-specific profiles.
  • Numerous genes are essential for extraembryonic structure formation.

Purpose of the Study:

  • To highlight the epigenetic machinery essential for extraembryonic cell differentiation and placental formation.
  • To review knockout models identifying sensitive stages in extraembryonic development.
  • To summarize epigenetically controlled mechanisms in placental development.

Main Methods:

  • Review of existing literature and data, particularly from mouse studies.
  • Analysis of knockout models to assess sensitivity to chromatin environment alterations.

Related Experiment Videos

  • Summary of established epigenetic mechanisms like imprinted gene expression and X chromosome inactivation.

    • Main Results:

    • Extraembryonic development and placental formation are critically dependent on epigenetic regulation.
    • Specific stages of extraembryonic development are highly sensitive to changes in the chromatin environment.
    • Imprinted gene expression and imprinted X chromosome inactivation are key epigenetic mechanisms in placental development.

    Conclusions:

    • Epigenetic machinery is fundamental for trophoblast differentiation and placental development.
    • Understanding epigenetic regulation provides insights into the dynamic chromatin environment of extraembryonic tissues.
    • These processes are crucial for normal mammalian embryo growth and survival.