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Published on: February 26, 2013
Export aspiration system in patients with acute coronary syndrome and visible thrombus provides no substantial
Hubertus V Korn1, Marc Ohlow, Stoycho Donev
1Department of Cardiology, Zentralklinik Bad Berka, Bad Berka, Germany. h.korn.kar@zentralklinik-bad-berka.de
Insights
The Export Aspiration System did not significantly improve outcomes for patients with acute coronary syndrome and visible thrombus compared to standard treatment. This study found no substantial benefit from using this thrombectomy device.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Medicine
Background:
- Visible thrombus is a known risk factor during percutaneous coronary intervention (PCI).
- Effective management of thrombus is crucial for successful PCI outcomes.
Purpose of the Study:
- To evaluate the efficacy of the Export Aspiration System in patients with acute coronary syndrome and angiographically visible thrombus.
- To compare outcomes of PCI with and without thrombectomy using the Export Aspiration System.
Main Methods:
- A retrospective analysis compared 79 patients treated with the Export Aspiration System (group 1) to 79 patients treated without a thrombectomy device (group 2).
- Both groups presented with acute coronary syndrome and visible thrombus between October 2004 and March 2005.
- Outcomes assessed included final TIMI flow, myocardial blush grade (MBG), and major adverse cardiac events (MACE).
Main Results:
- Final TIMI flow 3 or MBG 3 was achieved in 68.4% of group 1 versus 72.2% of group 2 (P = 0.6).
- Final TIMI flow 0 or MBG 0 occurred in 10.1% of group 1 versus 5.1% of group 2 (P = 0.23).
- The overall MACE rate during hospital stay was 11.4% in both groups.
Conclusions:
- The use of the Export Aspiration System in patients with acute coronary syndrome and visible thrombus does not offer substantial clinical benefits.
- Standard PCI without thrombectomy appears to yield comparable results in terms of flow, blush, and MACE rates.
Objective:
A visible thrombus remains a risk factor during percutaneous coronary intervention (PCI).
Methods:
Between October 2004 and March 2005, we treated all patients who consecutively presented with acute coronary syndrome + angiographically visible thrombus using the Export Aspiration System (group 1, n = 79). We retrospectively analyzed all consecutive patients who had been treated without a thrombectomy device (group 2, n = 79).
Results:
Final TIMI flow 3 or myocardial blush grade (MBG) 3 after completing PCI in group 1 and 2 was seen in 54 patients (68.4%) versus 57 patients (72.2%, P = 0.6) and in 45 patients (57.0%) versus 44 patients (55.7%, P = 0.9), respectively. Final TIMI flow 0 or MBG 0 in group 1 and 2 was observed in eight patients (10.1%) versus four patients (5.1%, P = 0.23) and in 24 patients (30.4%) versus 16 patients (20.3%, P = 0.15), respectively. HISTOLOGIC EVALUATION: Histologic evaluation revealed mostly mixed thrombotic material (83.6%). Microscopic material was seen in 91.8% of cases. MACE: Total MACE rate during hospital stay was 11.4% in both groups.
Conclusion:
Using the Export Aspiration System in patients presenting with acute coronary syndrome + visible thrombus provides no substantial benefit.
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