[Haemophilus parainfluenzae--a rare cause of endocarditis]

Dragan Ledina1, Jakica Karanović, Ivo Ivić

  • 1Odjel za zarazne bolesti, Klinicka bolnica Split, Split, Hrvatska. dledina@krizine.kbsplit.hr

Insights

This case study highlights Haemophilus parainfluenzae endocarditis, a rare infection, in a young athlete. Successful treatment involved a four-week intravenous course of amoxicillin-clavulanic acid and gentamicin.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • Haemophilus parainfluenzae endocarditis is a rare condition, often linked to oral procedures.
  • This case involves a young athlete with no prior heart conditions or risky medical exposures.

Observation:

  • The patient presented with peripheral embolizations, including splinter hemorrhages and petechiae.
  • A vegetation was identified on the dorsal mitral valve via echocardiography.
  • Blood cultures confirmed Haemophilus parainfluenzae after a seven-day incubation period.

Findings:

  • Treatment with intravenous amoxicillin-clavulanic acid and gentamicin for four weeks was initiated.
  • Subsequent oral therapy with amoxicillin-clavulanic acid continued for two weeks.
  • Echocardiography post-treatment revealed the complete disappearance of the endocardial vegetation.

Implications:

  • This case demonstrates a successful treatment protocol for a rare form of infective endocarditis.
  • Long-term follow-up confirmed no pathological aberrations, suggesting a favorable prognosis.
  • Highlights the importance of considering Haemophilus parainfluenzae in infective endocarditis, even without typical risk factors.

Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...