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Published on: February 23, 2014
[Haemophilus parainfluenzae--a rare cause of endocarditis]
Dragan Ledina1, Jakica Karanović, Ivo Ivić
1Odjel za zarazne bolesti, Klinicka bolnica Split, Split, Hrvatska. dledina@krizine.kbsplit.hr
Insights
This case study highlights Haemophilus parainfluenzae endocarditis, a rare infection, in a young athlete. Successful treatment involved a four-week intravenous course of amoxicillin-clavulanic acid and gentamicin.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Haemophilus parainfluenzae endocarditis is a rare condition, often linked to oral procedures.
- This case involves a young athlete with no prior heart conditions or risky medical exposures.
Observation:
- The patient presented with peripheral embolizations, including splinter hemorrhages and petechiae.
- A vegetation was identified on the dorsal mitral valve via echocardiography.
- Blood cultures confirmed Haemophilus parainfluenzae after a seven-day incubation period.
Findings:
- Treatment with intravenous amoxicillin-clavulanic acid and gentamicin for four weeks was initiated.
- Subsequent oral therapy with amoxicillin-clavulanic acid continued for two weeks.
- Echocardiography post-treatment revealed the complete disappearance of the endocardial vegetation.
Implications:
- This case demonstrates a successful treatment protocol for a rare form of infective endocarditis.
- Long-term follow-up confirmed no pathological aberrations, suggesting a favorable prognosis.
- Highlights the importance of considering Haemophilus parainfluenzae in infective endocarditis, even without typical risk factors.
Abstract:
Haemophilus parainfluenzae endocarditis is a rare acute or subacute disease. It is usually associated with dental and surgical procedures in the oral cavity. In a 23-year-old athlete admitted to Department of Infectious Diseases, Split University Hospital, the diagnosis of infective endocarditis was established based on Duke's criteria. The patient was not exposed to risky medical procedures nor he had a predisposing heart disease. The course of illness was characterized by peripheral embolizations (splinter hemorrhages and petechiae) and vegetation on the dorsal mitral valve. After seven days of incubation, blood cultures revealed Haemophilus parainfluenzae. The patient was treated intravenously with amoxicillin-clavulanic acid plus gentamicin for four weeks. Peroral therapy was continued with amoxicillin-clavulanic acid alone for two weeks. By the end of treatment, heart ultrasound showed disappearance of endocardial vegetation. Echocardiographic and clinical examinations performed at 3, 6 and 12 months of therapy showed no pathological aberrations.
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