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Updated: Jul 14, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
Low first-trimester hemoglobin and low birth weight, preterm birth and small for gestational age newborns
1Institute of Reproductive and Child Health, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100083, China. renag@sohu.com
Objective:
To examine the relationship between first-trimester hemoglobin (Hb) concentration and risk of low birth weight (LBW), preterm birth and small for gestational age (SGA).
Methods:
Data were obtained from a population-based prenatal care program in China. A total of 88,149 women who delivered during 1995-2000 and had their Hb measured in the first trimester were selected as study subjects.
Results:
The prevalence of anemia (Hb<110 g/L) was 22.1% in the first trimester. The risk of LBW, preterm birth and SGA was increased steadily with the decrease of first-trimester Hb concentration. After controlling for confounding factors, women with Hb 80-99 g/L had significantly higher risk for LBW (OR=1.44, 95% CI 1.17-1.78), preterm birth (OR=1.34, 95% CI 1.16-1.55) and SGA (OR=1.13, 95% CI 0.98-1.31) than women with Hb 100-119 g/L. No elevated risk was noted for women with Hb> or =120 g/L.
Conclusion:
Low first-trimester Hb concentration increases the risk of LBW, preterm birth and SGA.
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