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Updated: Jul 14, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
Importance of the echocardiographic evaluation of right ventricular function in patients with AL amyloidosis
Stefano Ghio1, Stefano Perlini, Giovanni Palladini
1Division of Cardiology, Fondazione IRCCS Policlinico S. Matteo and University of Pavia, 27100 Pavia, Italy. s.ghio@smatteo.pv.it
Background:
Patients with AL amyloidosis often present with signs of congestive heart failure.
Aim:
This study was prospectively designed to assess the significance of RV dysfunction in AL amyloidosis.
Methods And Results:
Seventy-four patients with biopsy proven AL amyloidosis underwent a thorough echocardiographic evaluation. A tricuspid annular plane systolic excursion (TAPSE)<17 mm was taken as marker of RV dysfunction. Plasma NT-proBNP determinations were performed in all cases. RV function was normal in 60 patients and reduced in 14 patients. Patients with RV dysfunction had thicker left ventricular (LV) walls (p<0.01), lower LV end-diastolic volumes (p<0.01), lower LV ejection fraction (p<0.01) and more frequently a restrictive LV filling pattern (p<0.01). RV dimensions and RV free wall thickness were not significantly different in the two groups. A thick interventricular septum and a reduced TAPSE were associated with high NT-proBNP levels (both p<0.01). Seven patients died during a median follow-up period of 19 months; TAPSE<17 mm was the only echocardiographic parameter associated with poor survival.
Conclusion:
In patients with AL amyloidosis, RV dysfunction is associated with more severe involvement of the left ventricle, higher plasma levels of NT-proBNP and with poor prognosis.
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