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Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay
Published on: August 6, 2020
Predicting memory: a prospective readout for malaria vaccines?
Gabriela Minigo1, Karen Scalzo, Katie L Flanagan
1Department of Immunology, Monash University, The Alfred Medical Research and Education Precinct, Prahran, Victoria 3181, Australia.
Abstract:
Malaria vaccines aim to induce long lasting protective immunity. Bejon and colleagues propose that levels of rapidly induced (effector memory) interleukin-2 and interferon gamma producing T-cells after vaccination with leading pre-erythrocytic stage vaccines predict the induction of resting memory responses (central memory). Herein we discuss Bejon's findings in the context of current thinking on the generation and maintenance of T cell memory, with particular emphasis on the role of cytokines.
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