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Updated: Jul 14, 2026

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Published on: October 19, 2011
Effects of anxiety on TNF-alpha levels during psychological stress
S Chandrashekara1, K Jayashree, H B Veeranna
1Chanre Rheumatology and Immunology Center, Clinical Immunology and Rheumatology, Bangalore, Karnataka, India. chandrashekara_s@yahoo.com
Objectives:
Psychological stress can influence the immune system, which may result in stress-related illnesses. In this study, we investigated the effect of psychological stress and the coping skill on plasma cytokine levels.
Materials And Methods:
One hundred eighty-three students, at different stages of an academic year, participated in this study. Plasma tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-2 soluble receptor alpha, and IL-4 were measured and examined in relation to the measures of anxiety [State Anxiety Inventory (SAI)] and Bell Adjustment Inventory (BAI) score.
Results:
SAI scores were significantly higher in both midterm students (MTS) and examination-taking students (ETS), compared with the freshly admitted students (FAS). In addition, TNF-alpha levels were significantly different between the high- and the low-anxiety groups of ETS but not in MTS or FAS. The correlation between SAI scores and the BAI emotional scores was highest in the ETS group.
Conclusions:
TNF-alpha level was significantly lower in the ETS group with high anxiety scores, and it is situation specific.
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