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Related Experiment Video

Updated: Jul 14, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Pediatric intraoperative floppy-iris syndrome.

M Edward Wilson¹, Rupal H Trivedi, Susannah Mistr

¹Miles Center for Pediatric Ophthalmology, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina 29425-5536, USA. wilsonme@musc.edu

Journal of Cataract and Refractive Surgery

|June 26, 2007

Summary

Epinephrine in irrigating solution prevented intraoperative floppy-iris syndrome (IFIS) during pediatric cataract surgery. This finding underscores the importance of epinephrine for preventing IFIS in infants.

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Last Updated: Jul 14, 2026

Iris Fixation via External Pentagram Suturing

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Area of Science:

Ophthalmology
Pediatric Surgery

Background:

Congenital cataracts require surgical intervention in infants.
Intraoperative floppy-iris syndrome (IFIS) is a known complication during cataract surgery.

Observation:

A 4-month-old infant underwent bilateral congenital cataract removal.
IFIS signs, including iris floppiness and prolapse, occurred in the left eye but not the right.
Epinephrine was omitted from the left eye's irrigating solution but used in the right.

Findings:

Intracameral epinephrine in the irrigating solution effectively prevented IFIS in the infant's right eye.
The omission of epinephrine in the left eye's irrigation correlated with the development of IFIS.

Implications:

This case highlights the critical role of intracameral epinephrine in preventing IFIS during pediatric cataract surgery.
Standardizing the use of epinephrine in pediatric cataract surgery irrigation may reduce intraoperative complications.