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Updated: Jul 14, 2026
09:31
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Antepartum percutaneous renal biopsy
D Wide-Swensson1, H Strevens, J Willner
1Department of Obstetrics and Gynecology, University Hospital, University of Lund, 221-85 Lund, Sweden. dag.wide-swenson@med.lu.se
Summary
Ultrasound-guided renal biopsy in pregnancy showed glomerular endotheliosis in pre-eclampsia patients and controls. Complications were minimal, but the procedure is hazardous for critically ill pregnant women with rapidly declining renal function.
Area of Science:
- Nephrology
- Obstetrics and Gynecology
- Medical Imaging
Background:
- Hypertensive disorders in pregnancy, including pre-eclampsia, are significant causes of maternal and fetal morbidity.
- Renal biopsy is a diagnostic tool, but its utility and safety in pregnancy require careful evaluation.
- Ultrasound guidance aims to improve the accuracy and safety of invasive procedures.
Purpose of the Study:
- To evaluate the diagnostic value of ultrasound-guided renal biopsy in pregnant women.
- To assess the safety and adverse effects of this biopsy technique during pregnancy.
- To differentiate between pre-eclampsia and other hypertensive disorders affecting the kidneys.
Main Methods:
- A cohort of 36 pregnant women with hypertensive disease (28 with pre-eclampsia) and 18 healthy controls underwent ultrasound-guided renal biopsy using a thin needle.
- Histopathological analysis of biopsy samples was performed to identify structural changes in the glomeruli.
- Adverse events, including retroperitoneal hematoma, were meticulously recorded.
Main Results:
- Glomerular endotheliosis was observed in all hypertensive women, with greater severity in pre-eclamptic cases.
- Similar glomerular changes were present in a significant proportion of healthy pregnant controls, questioning its specificity for pre-eclampsia.
- One serious complication, retroperitoneal hematoma, occurred in a patient with severe pre-eclampsia.
Conclusions:
- Glomerular endotheliosis is not a definitive marker for pre-eclampsia.
- Ultrasound-guided renal biopsy demonstrated a low complication rate in this study.
- Antepartum renal biopsy is likely not recommended for pregnant women with rapidly worsening renal function and edema due to diagnostic limitations and potential hazards.
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