Genetic structure of the nadA and nadB antivirulence loci in Shigella spp
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Updated: Jul 14, 2026

Epithelial Cell Infection Analyses with Shigella
Published on: February 9, 2024
Anne-Laure Prunier1, Raymond Schuch, Reinaldo E Fernández
1Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA.
Abstract:
Comparison of nadA and nadB in 14 Shigella strains and enteroinvasive Escherichia coli versus E. coli showed that at least one locus is altered in all strains. These observations explain the characteristic nicotinic acid auxotrophy of Shigella organisms and are consistent with the previously identified antivirulence nature of these genes for these pathogens.
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