Related Experiment Video
Updated: Jul 14, 2026
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Minute scirrhous hepatocellular carcinomas undergoing different carcinogenetic processes
Takahiko Fujii1, Yoh Zen, Yasuni Nakanuma
1Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Pathology International
|June 26, 2007
Summary
Scirrhous hepatocellular carcinoma (HCC), a rare liver cancer subtype, can arise from dysplastic nodules or develop de novo in cirrhotic livers. Further research is needed to clarify its early carcinogenic pathways.
Area of Science:
- Hepatobiliary Pathogenesis
- Oncology
- Gastroenterology
Background:
- Scirrhous hepatocellular carcinoma (HCC) is a rare subtype defined by significant fibrosis.
- Early carcinogenic processes and pathological features of scirrhous HCC are not well understood.
Observation:
- Two cases of minute scirrhous HCC with distinct origins were analyzed.
- Case 1: A 54-year-old man with HCV-related cirrhosis had a tumor with a nodule-in-nodule appearance, featuring scirrhous HCC within a high-grade dysplastic nodule.
- Case 2: A 75-year-old woman with NASH-related cirrhosis had an incidentally found scirrhous HCC developing de novo within the cirrhotic liver, without dysplastic nodule components.
Findings:
- Scirrhous HCC can originate from pre-existing dysplastic nodules.
- Scirrhous HCC can also arise independently (de novo) in the setting of liver cirrhosis.
Implications:
- These findings suggest divergent pathways for scirrhous HCC development.
- Understanding these distinct origins is crucial for early diagnosis and targeted therapies for scirrhous HCC.
More Related Videos
10:35Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
Published on: September 25, 2013
08:40A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
Published on: August 7, 2020
Related Concept Videos
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
01:24Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
01:25Mutagenicity and Carcinogenicity
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...