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Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
Published on: April 19, 2018
Mechanistic investigations of phase behavior in Eudragit E blends
1Polymer Science and Engineering Division, National Chemical Laboratory, Pune 411008, India.
International Journal of Pharmaceutics
|June 26, 2007
Summary
Eudragit E (EE) blends with polymeric excipients show tunable drug release. Polyelectrolyte complex formulation and swelling are key for sustained release, aiding in selecting components for tailored drug delivery.
Area of Science:
- Polymer Science
- Materials Science
- Pharmaceutical Sciences
Background:
- Eudragit E (EE) is a widely used polymer excipient in drug formulations.
- Understanding polymer-excipient interactions is crucial for developing effective drug delivery systems.
- Miscibility and complex formation influence drug release kinetics.
Purpose of the Study:
- To investigate the miscibility and interactions of Eudragit E (EE) with various polymeric excipients.
- To quantify these interactions using thermal analysis and FTIR spectroscopy.
- To correlate blend properties with drug release characteristics for tailored formulations.
Main Methods:
- Differential Scanning Calorimetry (DSC) for thermal analysis.
- Fourier Transform Infrared (FTIR) spectroscopy for interaction analysis.
- Schneider equation (parameters K1, K2) for quantifying miscibility.
Main Results:
- EE formed miscible blends with ethyl cellulose (EC) and polyelectrolyte complexes (PECs).
- Miscibility strength order: Eudragit E-Sodium Alginate (ES) < Hydroxypropyl Methylcellulose Phthalate (HPMCP) < Cellulose Acetate Phthalate (CAP) < Eudragit L (EL).
- Tg data determined EE weight fraction in PECs; stoichiometric ratios are important for formulation.
- Equilibrium swelling and K1 parameter correlated with sustained drug release duration.
Conclusions:
- EE-based PECs offer tunable drug release profiles.
- The study highlights the importance of stoichiometric formulation of PECs.
- Findings provide a basis for selecting blend constituents and compositions to control drug release duration.
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