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Updated: Jul 14, 2026
07:49
A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
Are cardiac events during exercise therapy for heart failure predictable from the baseline variables?
Isao Nishi1, Teruo Noguchi, Shinichi Furuichi
1Division of Cardiology, National Cardiovascular Center, Suita, Japan.
Summary
Patients undergoing exercise training for heart failure with a large left ventricular end-diastolic diameter (LVEDD) are at higher risk for cardiac events. Careful monitoring is recommended for these individuals during exercise programs.
Area of Science:
- Cardiology
- Exercise Physiology
Background:
- Exercise training (ET) shows promise for chronic heart failure management.
- Predictors of cardiac events (CEs) during ET in heart failure patients are not well-defined.
Purpose of the Study:
- To identify baseline patient characteristics that predict cardiac events during exercise training in stable heart failure patients.
Main Methods:
- Compared baseline characteristics of 15 patients experiencing CEs with 96 patients who did not during a 3-month ET program.
- Utilized multivariate logistic regression and receiver operating characteristic (ROC) curve analysis.
Main Results:
- Patients with CEs had higher prevalence of pacemakers/ICDs, larger left ventricular end-diastolic diameter (LVEDD), lower peak oxygen uptake, greater ventilation drive, and higher brain natriuretic peptide.
- A larger LVEDD was a significant predictor of CEs.
- LVEDD ≥ 65 mm predicted CEs with 93% sensitivity and 48% specificity.
Conclusions:
- Patients with LVEDD ≥ 65 mm require close monitoring during exercise training programs.
- Baseline LVEDD is a key factor in predicting cardiac events in heart failure patients undergoing ET.
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