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Relationship between angiographically documented coronary artery disease and low bone mass in men
Enver Erbilen1, Selma Yazici, Hakan Ozhan
1Department of Cardiology, Düzce University, Düzce, Turkey.
Background:
The present study aimed to investigate the association between low bone mass (LBM) and coronary artery disease (CAD) in male patients.
Method And Results:
The data for 47 men who were screened for osteopenia and osteoporosis with dual energy X-ray absorptiometry and then underwent coronary angiography between February 2005 and May 2006 were retrospectively analyzed. Bone mineral density of the femur neck was stratified as normal (T score >-1.0 SD) or low (T score <-1.0 SD) and CAD was defined as > or = 50% occlusion in at least 1 major coronary artery. Thirty-two patients were found to have angiographically significant CAD. Patients in the LBM group had a significantly higher incidence of CAD. Low bone mass was significantly and positively correlated with the Gensini scores of the patients (r=0.6037, p<0.0001) and was found to be an independent predictor of CAD in multivariate logistic regression analysis (odds ratio: 5.4 [95% confidence interval 1.66 and 17.49]; p=0.0049). Repeated statistical analyses with the acceptance of CAD as coronary artery stenosis >75% confirmed the same results.
Conclusion:
Low bone mass was significantly associated with angiographically documented CAD in males.
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