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Effect of olmesartan on oxidative stress in hemodialysis patients

Daisuke Kadowaki1, Makoto Anraku, Yuka Tasaki

  • 1Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|June 26, 2007
PubMed

Insights

Olmesartan, an angiotensin II receptor blocker, reduces oxidative stress in hemodialysis patients. This study shows olmesartan decreases oxidized albumin and albumin hydroperoxides, potentially offering benefits beyond blood pressure control.

Area of Science:

  • Nephrology
  • Cardiovascular Pharmacology
  • Oxidative Stress Research

Background:

  • Oxidative stress is a concern in hemodialysis (HD) patients.
  • The specific impact of olmesartan, an angiotensin II type 1 receptor blocker (ARB), on oxidative stress markers in HD patients requires further investigation.

Purpose of the Study:

  • To investigate the in vitro and in vivo effects of olmesartan on oxidative stress in hemodialysis patients.
  • To determine if olmesartan reduces oxidized albumin and albumin hydroperoxides.

Main Methods:

  • In vitro study: High-performance liquid chromatography (HPLC) and ferrous oxidation xylenol assay to measure oxidized albumin and albumin hydroperoxides with and without olmesartan.
  • In vivo study: Six hypertensive HD patients received 40 mg of olmesartan daily, with blood pressure and oxidized to unoxidized albumin ratio monitored over 8 weeks.

Main Results:

  • In vitro: Olmesartan significantly decreased oxidized albumin ratios and albumin hydroperoxides in a concentration-dependent manner.
  • In vivo: Olmesartan significantly reduced systolic and diastolic blood pressure within 4 weeks, with sustained reduction at 8 weeks.
  • In vivo: The ratio of oxidized to unoxidized albumin was markedly decreased after 4 weeks and maintained at 8 weeks.

Conclusions:

  • Olmesartan effectively reduces the oxidation of albumin both in vitro and in vivo.
  • The antioxidant effects of olmesartan in HD patients may provide benefits independent of its blood pressure-lowering action.

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