Campylobacter jejuni enterocolitis in neonates

A H Rashid1, H Salman, M I Hussain

  • 1Department of Pediatrics, Suleimania Children's Hospital, Riyadh, Saudi Arabia.

Insights

Campylobacter jejuni causes gastroenteritis in children. This study details six cases of neonatal enterocolitis from Campylobacter in Saudi Arabia, highlighting key symptoms like diarrhea, fever, and bloody stools.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Campylobacter jejuni is a major cause of childhood gastroenteritis.
  • Neonatal enterocolitis due to Campylobacter is rarely documented globally.
  • No prior cases were reported in Saudi Arabia.

Purpose of the Study:

  • To report the first cases of neonatal enterocolitis caused by Campylobacter jejuni in Saudi Arabia.
  • To describe the clinical presentation and management of these cases.

Main Methods:

  • Retrospective case series analysis.
  • Inclusion of six neonates diagnosed with Campylobacter enterocolitis between September 1989 and January 1991.
  • Review of patient records for symptoms, stool characteristics, and treatment.

Main Results:

  • Six neonates presented with diarrhea (1-20 days duration).
  • Three neonates had bloody stools, and two had mucus.
  • Five neonates exhibited fever, a finding contrasting with previous literature.
  • Various antibiotic treatments were administered, including erythromycin and augmentin.

Conclusions:

  • Campylobacter infection should be considered in neonates with diarrhea, especially when accompanied by mucus and blood.
  • Fever may be a more common presenting symptom in neonates than previously reported.

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...