Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Vitamins

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...

Role of Skin in Vitamin D Synthesis

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Connective Tissue Cell Types

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuraxial labor analgesia in a parturient with carnitine palmitoyl transferase type II deficiency: a case report.

International journal of obstetric anesthesia·2024

Same author

A compound chimeric antigen receptor strategy for targeting multiple myeloma.

Leukemia·2017

Same author

Effect of different concentrations of soybean lecithin and virgin coconut oil in Tris-based extender on the quality of chilled and frozen-thawed bull semen.

Veterinary world·2017

Same author

A phase 1b/2b multicenter study of oral panobinostat plus azacitidine in adults with MDS, CMML or AML with ⩽30% blasts.

Leukemia·2017

Same author

Effect of different concentrations of egg yolk and virgin coconut oil in Tris-based extenders on chilled and frozen-thawed bull semen.

Animal reproduction science·2017

Same author

Wind Generated Rogue Waves in an Annular Wave Flume.

Physical review letters·2017

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

Published on: June 24, 2025

Vitamin D deficiency rickets in Riyadh.

A Abanamy¹, H Salman, M Cheriyan

¹Suleimania Children's Hospital and College of Science, King Saud University, Riyadh, Saudi Arabia.

Annals of Saudi Medicine

|January 1, 1991

Summary

Vitamin D deficiency rickets is a significant health issue in Saudi Arabia, affecting infants and young children. Maternal deficiency and nutritional factors contribute to its high prevalence, necessitating improved detection and prevention strategies.

Related Experiment Videos

Last Updated: Jul 14, 2026

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

COVID-19 Seroprevalence Test for IgG Antibody Levels Among Healthy Donors Across Different Pandemic Phases in Jeddah

Published on: June 24, 2025

Area of Science:

Pediatrics
Nutritional Science
Public Health

Background:

Rickets, a condition caused by vitamin D deficiency, is unexpectedly common in Saudi Arabia despite abundant sunlight.
Contributing factors include nutritional, social, and maternal vitamin D deficiencies.
The study addresses the prevalence and characteristics of rickets in Saudi children.

Purpose of the Study:

To determine the incidence and clinical features of rickets in children admitted to Suleimania Children's Hospital in Riyadh.
To investigate the role of maternal vitamin D deficiency in early-onset rickets.
To highlight the need for enhanced detection, treatment, and prevention of rickets in Saudi Arabia.

Main Methods:

A retrospective review of 500 rickets cases out of 27,236 admissions over three years (1986-1988).
Analysis of patient demographics, age at onset, and presenting symptoms.
Comparison of findings with existing literature on rickets prevalence and age of onset.

Main Results:

Rickets was identified in 500 pediatric admissions (1.8%), with 81% being Saudi nationals.
The mean age of onset was significantly younger (8.2 months) than typically reported, with 39.2% younger than six months.
Common presenting symptoms included recurrent chest infections (66%) and hypocalcemic convulsions (17.2%).

Conclusions:

Rickets represents a major public health concern in Saudi Arabia.
Early onset and high prevalence suggest a significant role of maternal vitamin D deficiency.
There is an urgent need for improved strategies for rickets detection, treatment, and prevention in the region.