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Crohn's disease in Arabs.

J Hossain1, I A Al-Mofleh, M A Laajam

  • 1Division of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Annals of Saudi Medicine
|January 1, 1991
PubMed
Summary
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Crohn

Area of Science:

  • Gastroenterology and Internal Medicine

Background:

  • Crohn's disease is well-documented in Western populations.
  • Its prevalence and characteristics in the Middle Eastern community are less understood.

Purpose of the Study:

  • To investigate the occurrence and clinical presentation of Crohn's disease in Arab patients.
  • To analyze the diagnostic methods, treatment approaches, and outcomes in this demographic.

Main Methods:

  • Retrospective analysis of seven Arab patients diagnosed with Crohn's disease.
  • Inclusion of Saudi Nationals, with data on age, symptom duration, and disease location.
  • Review of diagnostic procedures (histology, colonoscopy) and treatment modalities (surgery, medical therapy).

Main Results:

  • Seven Arab patients (three Saudi Nationals) diagnosed with Crohn's disease.

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  • Mean age 32.4 years; symptom duration ranged from 3 months to 10 years.
  • Ileocolic (n=5) and colonic (n=2) disease sites; mass lesions in three patients.
  • Diagnosis via laparotomy/resection (n=4) and colonoscopic biopsy (n=3).
  • Extraintestinal manifestations in three patients.
  • Treatment included surgery alone (n=2) or medical therapy (steroids) with or without surgery.
  • Observed milder systemic effects compared to Western cohorts.

    • Conclusions:

    • Crohn's disease is present in the Arab population.
    • The disease presentation may differ, potentially with milder systemic effects.
    • Further research is warranted to understand Crohn's disease epidemiology in the Middle East.