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Functional insights from structural genomics.

Farhad Forouhar1, Alexandre Kuzin, Jayaraman Seetharaman

  • 1Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, NY 10027, USA.

Journal of Structural and Functional Genomics
|June 26, 2007
PubMed
Summary

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This summary is machine-generated.

Structural genomics provides protein structures, aiding functional discovery. The Northeast Structural Genomics Consortium (NESG) identified novel protein functions, including enzymes and immunity factors, through structure-guided analysis.

Area of Science:

  • Structural biology
  • Proteomics
  • Biochemistry

Background:

  • Structural genomics initiatives have generated extensive protein structural data.
  • A significant portion of these proteins lack characterized functions.
  • Protein structures offer potential for functional insights.

Purpose of the Study:

  • To report functional discoveries derived from structural analyses of proteins.
  • To highlight the utility of structural information in characterizing unknown proteins.

Main Methods:

  • Structure determination (direct or modeling) through structural genomics.
  • Structure-based functional analysis and screening.
  • Case studies from the Northeast Structural Genomics Consortium (NESG).

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Main Results:

  • Identification of a novel methyl salicylate esterase involved in plant immunity.
  • Characterization of a novel RNA methyltransferase (HI0303) from H. influenzae.
  • Discovery of a novel spermidine/spermine N-acetyltransferase (PaiA) in B. subtilis.
  • Identification of a novel methyltransferase/AdoMet binding protein (AF_0241) from A. fulgidus.
  • Characterization of ATP:cob(I)alamin adenosyltransferase (YvqK) in B. subtilis.
  • Discovery of a novel carboxysome pore protein (EutN) in E. coli.
  • Analysis of a proline racemase homolog with a disrupted active site (BME11586) from B. melitensis.
  • Characterization of an FMN-dependent enzyme (SP_1951) from S. pneumoniae.
  • Identification of a novel 12-stranded beta-barrel fold (VPA1032) from V. parahaemolyticus.

Conclusions:

  • Structural genomics is a powerful approach for uncovering novel protein functions.
  • Structure-guided analysis accelerates the functional characterization of unannotated proteins.
  • NESG has successfully contributed to the discovery of diverse novel protein functions.