Related Experiment Video
Updated: Jul 14, 2026
09:59
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Enhanced dissolution of oxcarbazepine microcrystals using a static mixer process
1Department of Pharmaceutical Technology, Friedrich-Schiller University of Jena, Lessing Strasse 8, D-07743 Jena, Germany. dionysios.douroumis@phoqus.com
Colloids and Surfaces. B, Biointerfaces
|June 26, 2007
Summary
Researchers developed micronized Oxcarbazepine (OXC) powders using a static mixer technique. This method enhances the dissolution rate of poorly soluble drugs, offering a scalable and efficient process.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Oxcarbazepine (OXC) is a poorly water-soluble drug.
- Enhancing dissolution rates is crucial for improving drug bioavailability.
Purpose of the Study:
- To create micronized Oxcarbazepine (OXC) powders using a static mixer technique.
- To improve the dissolution rate of OXC.
Main Methods:
- Controlled precipitation of OXC by rapid injection into a methylcellulose (MC) solution using a static mixer.
- Factorial design for data analysis.
- Physicochemical characterization using DSC, FTIR, and XRD.
Main Results:
- Micronized OXC powders with a mean particle size of approximately 2 micrometers and high drug loading were produced.
- Drug remained crystalline with no drug-polymer interactions observed.
- Enhanced dissolution rate of OXC microcrystals compared to pure OXC.
Conclusions:
- The static mixer technique is effective for producing micro-sized polymeric particles of poorly soluble drugs.
- This technique is inexpensive, time-efficient, and scalable for drug development.
Related Concept Videos
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
01:13In Vitro Drug Dissolution: Compendial Testing Models I
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
01:17In Vitro Drug Dissolution: Alternative Methods
Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
01:09In Vitro Drug Dissolution: Compendial Testing Models II
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...