[A comparative study of properties of paracetamol tablets of the matrix type]

Our study was to compare the quantitative and qualitative effects of 2 polymeric agents (méthylcellulose, hydroxypropylmethylcellulose) and of 2 diluants (lactose and dicalcic phosphate) on the compression properties and sustained liberation of acetaminophen matrixes. Three experimental plans were permitted the experimentation; regression equations were used for our analysis of the results. The results we obtained show the superiority importance of the effect of the diluant/acetaminophen ratio over the liberation of the drug, as well as the better efficiency of méthylcellulosic matrixes. Thence to its solubility, the lactose helps to a faster liberation.