Association of Helicobacter pylori and nonulcer dyspepsia

The etiology and pathogenesis of nonulcer dyspepsia (NUD) are not completely understood and consequently, no specific medication can be prescribed to the sufferers. We studied 69 cases, proved clinically, laboratorally, sonographically and endoscopically, to have NUD. Antral biopsy was taken from every case and subjected to CLO test. Out of the 69 patients, 51 (74%) were infected with Helicobacter pylori (HP). Oral medication, consisting of amoxacillin 500 mg, metronidazol 500 mg, and bismuth mixture, 5 mls three times daily was prescribed for four weeks. Out of the 51 patients at the end of four weeks, 46 cases (90%) were cleared of HP, and only 38 cases (74.5%) experienced complete improvement of their dyspeptic symptoms. We arrived at the conclusion that a good percentage of NUD patients can be cured by the use of the 3-drug combination.