Related Experiment Video
Updated: Jul 14, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
Necrotizing gingivitis: a possible oral manifestation of ticlopidine-induced agranulocytosis
Rama Krsna Rajandram1, Roszalina Ramli, Fadzlina Karim
1Oral & Maxillofacial Surgery, Hospital Universiti Kebangsaan, Kuala Lumpur, Malaysia.
Abstract:
Agranulocytosis is a rare complication of ticlopidine and can be life-threatening. We report a case of ticlopidine-induced agranulocytosis and neutropenia (neutrophil count of 0.1 x 10(9)/L) with necrotizing gingivitis in a 54-year-old Malaysian-Chinese female. She was started on ticlopidine 250 mg twice daily 3 weeks prior to this hospital admission. We started her on intravenous metronidazole and amoxicillin and clavulanic acid (Augmentin) and concurrently stopped ticlopidine. A series of clinical and laboratory investigations were carried out and a final diagnosis of necrotizing gingivitis possibly secondary to agranulocytosis was made. The patient was discharged home after 2 weeks of hospitalisation.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
The Oral Microbiota
Transient Ischemic Attack l: Introduction
Cryptococcal Meningitis
Diphtheria
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.