Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electrical Impedance Correlated to Flow Rate in Elastomeric Valves: An Analog Material Memory.

ACS applied materials & interfaces·2025

Same author

Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering.

Proceedings of the National Academy of Sciences of the United States of America·2024

Same author

Predicting Clinical Outcomes of SARS-CoV-2 Drug Efficacy with a High-Throughput Human Airway Microphysiological System.

Advanced biology·2024

Same author

Thirtieth Anniversary of Tissue Engineering: A Congratulations and a Few Thoughts.

Tissue engineering. Part A·2024

Same author

First 24-Hour-Long Intensive Care Unit Testing of a Clinical-Scale Microfluidic Oxygenator in Swine: A Safety and Feasibility Study.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2024

Same author

A High-Throughput, High-Containment Human Primary Epithelial Airway Organ-on-Chip Platform for SARS-CoV-2 Therapeutic Screening.

Cells·2023

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

Microfabrication of three-dimensional engineered scaffolds.

Jeffrey T Borenstein¹, Eli J Weinberg, Brian K Orrick

¹Biomedical Engineering Center, Charles Stark Draper Laboratory, Cambridge, Massachusetts 02139, USA. jborenstein@draper.com

Tissue Engineering

|June 26, 2007

Summary

Microfabrication technologies enable precise cellular microenvironment engineering for tissue engineering. This approach is vital for creating functional organ assist devices and engineered tissues for clinical benefit.

More Related Videos

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Published on: March 12, 2014

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Related Experiment Videos

Last Updated: Jul 14, 2026

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Manufacturing of Three-dimensionally Microstructured Nanocomposites through Microfluidic Infiltration

Published on: March 12, 2014

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Area of Science:

Biotechnology
Materials Science
Regenerative Medicine

Background:

Tissue engineering faces challenges in creating large-scale constructs with organized cellular microenvironments.
Microfluidic systems are crucial for developing viable engineered tissues for organ assist and replacement.

Purpose of the Study:

To present an overview of microfabrication technologies for tissue engineering.
To summarize progress in applying these technologies to organ-specific constructs.

Main Methods:

Utilizing microfabrication techniques like photolithography, etching, molding, and lamination.
Employing biocompatible and biodegradable polymeric scaffolding materials.
Leveraging computational fluid dynamic designs for scaffold development.

Main Results:

Microfabrication provides a versatile approach for precisely engineered tissue scaffolds.
Established fabrication processes support various polymeric materials.
Computational fluid dynamics-driven designs have been translated into 3D scaffolds.

Conclusions:

Microfabrication is a key technology for advancing tissue engineering.
Progress has been made in applications for liver and kidney tissue engineering.
This technology holds promise for future clinical applications in organ regeneration.