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The identification of potent, selective, and bioavailable cathepsin S inhibitors
Jacques Yves Gauthier1, W Cameron Black, Isabelle Courchesne
1Merck Frosst Centre for Therapeutic Research, Department of Medicinal Chemistry, Kirkland, QUE, Canada. jacques-yves_gauthier@merck.com
Bioorganic & Medicinal Chemistry Letters
|June 26, 2007
Abstract:
Highly potent, selective, and bioavailable inhibitors of human, mouse, or rat cathepsin S are described. The key structural features combine a sulfonyl moiety attached to a large group in P2 and a small substituent in P3.
