Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intrathecal Delivery of a Test Compound to the Rat Central Nervous System05:04

Intrathecal Delivery of a Test Compound to the Rat Central Nervous System

607
Source: Chen, Y., et al. Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System. J. Vis. Exp. (2019)This video demonstrates the delivery of a test compound into the cerebrospinal fluid (CSF) through a catheter implanted in the lumbar spinal column of a rat model. The compound circulates along the CSF to the brain and spinal cord, enters neurons, and offers therapeutic...
607
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

14.0K
Optical clearing techniques are revolutionizing the way tissues are visualized. In this report we describe modifications of the original Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging-compatible Tissue-hYdrogel (CLARITY) protocol that yields more consistent and less expensive...
14.0K
Culturing Microglia from the Neonatal and Adult Central Nervous System11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

28.8K
We outline methods for the efficient and quick isolation/culture of viable microglia from the neonatal cerebral cortex and adult spinal cord. The dissection and plating of cortical microglia can be accomplished within 90 minutes, with the subsequent microglial harvest taking place ~ 10 days following the initial...
28.8K
Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System14:55

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

61.7K
We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to...
61.7K
Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE20:51

Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE

16.7K
In this video we demonstrate how to isolate mononuclear cells from the central nervous system of rats with experimental autoimmune encephalomyelitis.
16.7K
Generation of a Murine Model with a Central Nervous System Infection02:21

Generation of a Murine Model with a Central Nervous System Infection

494
This video demonstrates the generation of a mouse model with a CNS infection. A suckling pup is injected with the virus both intracranially and intraperitoneally. The virus spreads, infecting the CNS causing neuronal cell death and inflammation. The pup is assessed for symptoms of infection as the disease...
494

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EBV and immunodeficiency: the odd couple drawn to the brain.

Blood·2026
Same author

Application of Hi-C sequencing to detect oncogene rearrangements for diagnosis and treatment of large B-cell lymphoma.

Blood advances·2026
Same author

Beyond biomarkers: tissue still matters.

The Lancet. Haematology·2026
Same author

SOHO State of the Art Updates and Next Questions | Management of Primary Central Nervous System Lymphoma.

Clinical lymphoma, myeloma & leukemia·2026
Same author

Addition of autologous stem-cell transplantation to an ibrutinib-containing first-line treatment in patients aged 18-65 years with mantle cell lymphoma (TRIANGLE): 4·5-year follow-up of a three-arm, randomised, open-label, phase 3 superiority trial of the European MCL Network.

Lancet (London, England)·2026
Same author

Hepatitis C virus and hepatitis B virus in indolent lymphomas: Prospective data from the international observational NF10 study.

British journal of haematology·2026

Related Experiment Video

Updated: Jan 20, 2026

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.0K

Primary central nervous system lymphoma.

Andrés J M Ferreri1, Michele Reni

  • 1Medical Oncology Unit, San Raffaele Scientific Institute, Milan, Italy. andres.ferreri@hsr.it

Critical Reviews in Oncology/Hematology
|June 26, 2007
PubMed
Summary
This summary is machine-generated.

Primary central nervous system lymphomas (PCNSL) are aggressive brain cancers with poor prognoses. Despite advances, optimal treatment for PCNSL remains challenging, with high relapse rates and unanswered therapeutic questions.

More Related Videos

Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.8K
Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE
20:51

Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE

Published on: December 3, 2007

16.7K

Related Experiment Videos

Last Updated: Jan 20, 2026

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.0K
Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.8K
Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE
20:51

Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE

Published on: December 3, 2007

16.7K

Area of Science:

  • Neuro-oncology
  • Hematology
  • Immunology

Background:

  • Primary central nervous system lymphomas (PCNSL) are aggressive malignancies with unique characteristics.
  • PCNSL has one of the worst prognoses among non-Hodgkin lymphomas (NHL).
  • Radiotherapy (RT) and chemotherapy have improved survival but challenges remain.

Purpose of the Study:

  • To review the current therapeutic landscape for PCNSL.
  • To identify persistent challenges and unanswered questions in PCNSL management.
  • To highlight the need for optimized therapeutic strategies.

Main Methods:

  • Review of existing literature on PCNSL treatment.
  • Analysis of response rates, survival data, and relapse patterns.
  • Evaluation of challenges in defining optimal therapeutic management.

Main Results:

  • Radiotherapy (RT) yields a 60-65% response rate but is often followed by relapse.
  • Systemic chemotherapy has improved survival, yet prognosis remains dismal.
  • High rates of local relapse and death persist despite treatment advances.

Conclusions:

  • Optimal therapeutic management for PCNSL is difficult to define due to study limitations.
  • Significant therapeutic questions in PCNSL remain unanswered.
  • Further research is needed to improve outcomes for PCNSL patients.