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BDNF plasma levels in acute stroke.

V Di Lazzaro1, P Profice, F Pilato

  • 1Institute of Neurology, Università Cattolica, L.go A. Gemelli 8, 00168 Rome, Italy. vdilazzaro@rm.unicatt.it

Neuroscience Letters
|June 26, 2007
PubMed
Summary
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This study found that plasma levels of brain-derived neurotrophic factor (BDNF) did not significantly increase in stroke patients, even with blood-brain barrier (BBB) disruption. This suggests limited endogenous BDNF entry into circulation post-stroke.

Area of Science:

  • Neuroscience
  • Neurology
  • Biochemistry

Background:

  • Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal survival and function.
  • Transport of BDNF across the blood-brain barrier (BBB) is limited under normal physiological conditions.
  • Pathological conditions like stroke may compromise BBB integrity, potentially allowing BDNF to cross.

Purpose of the Study:

  • To investigate the plasma levels of BDNF during the acute phase of stroke in human patients.
  • To assess the relationship between BDNF levels and blood-brain barrier (BBB) disruption following stroke.

Main Methods:

  • Serial venous blood sampling from ten acute stroke patients over 5 days.
  • Measurement of plasma BDNF concentrations.
  • Evaluation of plasma S100beta protein levels as a marker of BBB disruption.

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Main Results:

  • No significant changes in plasma BDNF levels were observed throughout the study period in stroke patients.
  • S100beta protein concentrations significantly increased at days 2 and 3 post-stroke, indicating BBB dysfunction.
  • BDNF levels remained unchanged despite evidence of pronounced BBB disruption.

Conclusions:

  • The findings suggest that endogenous extracellular BDNF does not significantly increase in the plasma during the acute phase of human stroke.
  • This implies limited migration of BDNF across a disrupted BBB into the systemic circulation post-stroke.
  • Further research is needed to fully elucidate BDNF's role and transport dynamics in stroke pathophysiology.