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New sphingolipids from the root of Isatis indigotica and their cytotoxic activity
Xiang Li1, Dong-Dong Sun, Jian-Wei Chen
1Nanjing University of Traditional Chinese Medicine, 210029, Jiangsu, People's Republic of China. sdd.426910@163.com
Abstract:
Two new sphingolipids were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as (2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(1) and 1-O-beta-D-glucopyranosyl-(2S,3R)-3-hydroxymethyl-N-(2'-hydroxynonacosanoyl)-trideca-9E-sphingenine(2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method.
