Related Experiment Video

Updated: Jul 14, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

Enteric fever due to multi-resistant Salmonella typhi

A M Kambal1, S Al-Sugair, S R Al-Ballaa

  • 1Department of Medicine and Department of Pathology and Microbiology, King Khalid University Hospital, Riyadh, Saudi Arabia.

Annals of Saudi Medicine
|May 1, 1993
PubMed

Insights

Multi-resistant Salmonella typhi caused enteric fever in five patients, likely contracted in India or Egypt. Effective treatment was achieved using ceftriaxone or ciprofloxacin, highlighting successful therapeutic options for this resistant bacterial infection.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Enteric fever, primarily caused by Salmonella Typhi, presents a significant global health challenge.
  • The emergence of multi-drug resistant (MDR) strains of Salmonella Typhi complicates treatment strategies.
  • Travelers

Purpose of the Study:

  • To report cases of enteric fever caused by multi-resistant Salmonella Typhi.
  • To document the geographical origins of infection.
  • To evaluate treatment outcomes with specific antibiotics.

Main Methods:

  • Case series reporting.
  • Clinical data collection.
  • Treatment outcome analysis.

Main Results:

  • Five cases of enteric fever due to multi-resistant Salmonella Typhi were identified.
  • Four cases were likely acquired in India, and one in Egypt.
  • All patients responded successfully to treatment with either ceftriaxone or ciprofloxacin.

Conclusions:

  • Ceftriaxone and ciprofloxacin are effective treatment options for multi-resistant Salmonella Typhi.
  • Travelers returning from endemic regions like India and Egypt are at risk.
  • Continued surveillance for MDR Salmonella Typhi is crucial.

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...