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Remission in diabetic children in Riyadh
1Suleimania Children's Hospital, Riyadh, Saudi Arabia.
Annals of Saudi Medicine
|September 1, 1991
Summary
Temporary remission in children with insulin-dependent diabetes mellitus (IDDM) was studied in Riyadh. The partial remission rate was 32.1%, influenced by age, parental relation, and sex, with improved C-peptide levels indicating temporary pancreatic B-cell recovery.
Area of Science:
- Pediatrics
- Endocrinology
- Metabolic Disorders
Background:
- Limited data exist on temporary remission in pediatric insulin-dependent diabetes mellitus (IDDM) in Riyadh.
- Understanding remission patterns is crucial for managing pediatric diabetes.
Purpose of the Study:
- To investigate the rate and characteristics of temporary remission in children with IDDM in Riyadh.
- To identify factors influencing remission and assess changes in glycemic control and pancreatic B-cell function.
Main Methods:
- Retrospective study of 115 children diagnosed with IDDM between 1985 and mid-1990.
- Analysis of remission rates, patient demographics, clinical presentation, treatment parameters, and biochemical markers (HbA1c, C-peptide).
Main Results:
- A partial temporary remission rate of 32.1% was observed.
- Higher remission rates were noted in children over five years old, of unrelated parents, and females.
- Remission was associated with improved glycemic control (HbA1c 7.4% vs 12.3%), reduced insulin dosage, and enhanced C-peptide levels, indicating temporary pancreatic B-cell function recovery.
Conclusions:
- The observed remission rate of 32.1% in pediatric IDDM patients in Riyadh is likely influenced by a young age distribution at onset and potentially a different disease severity pattern.
- Temporary recovery of pancreatic B-cell function is evident during remission.
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