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Peripheral neuropathy in oxalosis. A case report with electron microscopic observations
Summary
Chronic kidney disease patients on hemodialysis may develop peripheral neuropathy due to oxalate crystal deposition in nerves. This study details nerve damage caused by oxaluria in a hemodialysis patient.
Area of Science:
- Nephrology
- Neurology
- Pathology
Background:
- Chronic renal failure due to oxaluria and renal calculi.
- Patient underwent chronic hemodialysis treatment.
Observation:
- Developed severe, progressive peripheral neuropathy two years prior to death.
- Autopsy revealed calcium oxalate crystals in peripheral nerves and other tissues.
Findings:
- Nerve lesions included segmental demyelination and axonal degeneration.
- Crystalline deposits were observed within the myelin sheath.
- Ultrastructural analysis showed oxalate deposits in Schwann cells and endoneurium.
Implications:
- Chronic hemodialysis may promote oxalate deposition in Schwann cells.
- This deposition is linked to neuropathy development in primary hyperoxaluria patients with renal failure.