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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Published on: May 5, 2022

Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes

Shivendra D Shukla1, Youn Ju Lee, Pil-hoon Park

  • 1Department of Medical Pharmacology & Physiology, University of Missouri School of Medine, Columbia, MO 65212, USA.

Novartis Foundation Symposium
|June 27, 2007
PubMed

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Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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