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Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

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Updated: Jul 14, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

An update on pruritus associated with CKD.

Tejesh S Patel¹, Barry I Freedman, Gil Yosipovitch

¹Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

|June 27, 2007

Summary

Chronic kidney disease (CKD) and end-stage renal disease prevalence is rising globally. CKD-associated pruritus significantly impacts patient quality of life and outcomes, yet remains underrecognized and undertreated.

Related Experiment Videos

Last Updated: Jul 14, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Nephrology
Dermatology
Public Health

Background:

Global rise in chronic kidney disease (CKD) and end-stage renal disease.
CKD-associated pruritus is a prevalent, distressing symptom impacting quality of life and patient outcomes.
Inadequate recognition and management of CKD-associated pruritus by healthcare professionals.

Purpose of the Study:

Highlight the significance of CKD-associated pruritus as a neglected topic.
Provide an overview of current knowledge on CKD-associated pruritus.
Summarize recent epidemiological data, outcomes, mechanisms, and treatments.

Main Methods:

Review of recent epidemiological studies.
Analysis of outcomes data related to CKD-associated pruritus.
Exploration of proposed pathophysiological mechanisms.
Examination of emerging treatment options.

Main Results:

CKD-associated pruritus negatively affects patient quality of life and sleep.
Evidence links pruritus to poorer patient outcomes in CKD.
Pathophysiological mechanisms of pruritus in CKD are not well-defined.
Development of targeted therapies remains challenging.

Conclusions:

CKD-associated pruritus is a significant public health issue requiring greater attention.
Further research into mechanisms and treatments is crucial for improved patient care.
Multidisciplinary approaches are needed to effectively manage this symptom.