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Cerebral aneurysms associated with neurofibromatosis
M G Muhonen1, J C Godersky, J C VanGilder
1Division of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City 52242.
Surgical Neurology
|December 1, 1991
Summary
Neurofibromatosis (NF) can cause rare artery issues like cerebral aneurysms. This study highlights three patients with NF and five aneurysms, suggesting a link between NF and these vascular complications.
Area of Science:
- Neuroscience
- Vascular Surgery
- Genetics
Background:
- Neurofibromatosis (NF) is a genetic disorder with various complications.
- Intracranial and extracranial arterial disease is an uncommon manifestation of NF.
- Previous cases often mimicked Moyamoya disease.
Observation:
- Three patients with neurofibromatosis (NF) were treated over three years.
- These patients presented with a total of five cerebral aneurysms.
- Four aneurysms were intracranial, with two being fusiform.
Findings:
- Surgical occlusion was performed, utilizing Selverstone clamping, balloon occlusion, and direct clipping.
- A significant association between neurofibromatosis and cerebral artery aneurysms is suggested.
- The underlying pathophysiology of these vascular changes remains unclear.
Implications:
- This association warrants further investigation into the mechanisms linking NF and cerebral aneurysms.
- Understanding this link may improve diagnostic and treatment strategies for NF patients.
- Further research is needed to elucidate the pathophysiology and guide clinical management.