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Gastropathy and gastritis in children with portal hypertension

Nahida El-Rifai1, Karine Mention, Dominique Guimber

  • 1Department of Pediatric Gastroenterology, Jeanne de Flandre Hospital, France. nahidarif@yahoo.fr

Journal of Pediatric Gastroenterology and Nutrition
|June 27, 2007
PubMed

Insights

Portal hypertensive gastropathy (PHG) and gastritis are common in children with portal hypertension. PHG links to esophageal varices and bleeding, while gastritis associates with cirrhosis, regardless of the hypertension cause.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Clinical Medicine

Background:

  • Portal hypertension in children can stem from liver disease or extrahepatic venous obstruction.
  • Gastrointestinal complications like gastropathy and gastritis are potential sequelae.
  • Understanding their frequency and associated factors is crucial for pediatric patient management.

Purpose of the Study:

  • To determine the prevalence of portal hypertensive gastropathy (PHG) and gastritis in pediatric patients with portal hypertension.
  • To identify factors associated with the development of PHG and gastritis in this cohort.

Main Methods:

  • Retrospective analysis of 24 children diagnosed with portal hypertension.
  • Clinical data review for esophageal varices and hematemesis history.
  • Histological examination of gastric biopsies for gastritis assessment.

Main Results:

  • Portal hypertensive gastropathy (PHG) was observed in 14 out of 24 patients (58.3%).
  • PHG showed a significant association with the presence of esophageal varices and a history of hematemesis.
  • Gastritis was histologically confirmed in 14 out of 24 patients (58.3%) and significantly associated with cirrhosis.

Conclusions:

  • Portal hypertensive gastropathy (PHG) is a frequent finding in children experiencing portal hypertension.
  • The development of PHG in children appears independent of the underlying cause of portal hypertension.
  • Gastritis is also common and linked to cirrhosis in this pediatric population.

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