Penoscrotal histoplasmosis following bladder carcinoma

Histoplasmosis is caused by a dimorphic fungus Histoplasma capsulatum. Transmission is via inhalation and lungs are the most commonly affected site. Other sites are involved uncommonly and genitals are rarely involved. The case is reported herein of a man with penoscrotal histoplasmosis following bladder carcinoma that had been treated with intravesical bacille Calmette-Guerin. He presented with multiple ulcers on the penis and scrotum that coalesced, followed by the appearance of cutaneous lesions. The condition responded well to itraconazole. To the best of our knowledge, this is the first case of penoscrotal histoplasmosis following bladder carcinoma.