Related Experiment Video
Updated: Jul 14, 2026

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
The role of heart rate in the development of cardiovascular disease
1Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Kirrberger Strasse, 66421, Homburg/Saar, Germany. reil@med-in.uni-saarland.de
Insights
Elevated heart rate is a significant risk factor for cardiovascular diseases like hypertension and heart failure. Monitoring heart rate offers a simple method to assess prognosis and treatment effectiveness in patients.
Area of Science:
- Cardiology
- Clinical Medicine
- Physiology
Background:
- Heart rate is an independent risk factor for cardiovascular disease.
- Conditions include arterial hypertension, myocardial infarction, coronary artery disease, and heart failure.
Purpose of the Study:
- To summarize evidence on the relationship between heart rate and cardiovascular disease.
- To highlight the prognostic and therapeutic implications of heart rate monitoring.
Main Methods:
- Review of animal studies.
- Analysis of clinical trials.
- Summary of existing research.
Main Results:
- Increased heart rate has detrimental effects on cardiovascular function and structure.
- Heart rate is a readily measurable clinical parameter.
Conclusions:
- Heart rate is a crucial independent risk factor in cardiovascular disease.
- Simple heart rate detection aids in prognosis and therapy evaluation.
Abstract:
Heart rate is an independent risk factor for patients with cardiovascular disease, in particular with arterial hypertension, myocardial infarction, coronary artery disease and heart failure. This relation is supported by a large number of animal studies as well as clinical trials which are summarized in this article. These studies demonstrated detrimental effects of increased heart rate on the function and structure of the cardiovascular system. Heart rate can be easily detected during physical examination of the patient and therefore allows a simple conclusion on prognosis and efficiency of therapy.
Related Concept Videos
Factors Influencing Heart Rate
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Regulation of Heart Rates
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
Pathophysiology of Cardiac Performance
Coronary Artery Disease I: Introduction
Decreased pulse rate
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with bradycardia...
Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
