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Published on: October 21, 2022
[In vitro microstructural analysis of commercial ophthalmic suspensions by HRT II Rostock Cornea Module]
1Klinik für Augenheilkunde, Semmelweis Universität Budapest, Tömo u.25-29, 1083, Budapest, Ungarn. imrelaszlo@t-online.hu
Background:
To investigate the particles of commercially used ophthalmic suspensions with the HRT II Rostock Cornea Module and to compare them with particle parameters given in the literature.
Methods:
Software-aided analysis was carried out for the suspensions brinzolamide 1%, betaxolol HCl 0.25%, dexamethasone phosphate 0.1% and prednisolone acetate 0.5%, including measurements of length, area and circumference and calculation of ellipticity and shape factor (SF).
Results:
Particle characteristics (SF and ellipticity) of different suspensions demonstrated that the particles are not spherical. Significant aggregation affinity of prednisolone acetate particles was observed.
Conclusion:
Exact and reproducible in vitro microstructural examination of ophthalmic suspensions was possible due to the high resolution of the HRT II Rostock Cornea Module.
