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Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
Published on: January 16, 2013
Anti-MPO small-vessel vasculitis causing prostatis and nephritis.
Jorge A Lamarche1, Alfredo M Peguero2, Joaquin O Rosario2
1James A. Haley Veterans Hospital, University of South Florida, 13000 Bruce B. Downs Blvd. Nephrology Department 7B West 105, Tampa, Fl33612, USA. jorgelamarche75@yahoo.com.
Clinical and Experimental Nephrology
|June 27, 2007
Summary
Microscopic polyangiitis, a small-vessel vasculitis, can affect the prostate. This case highlights anti-myeloperoxidase (anti-MPO) antibody vasculitis presenting with prostatic involvement, a rare but critical diagnosis.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Microscopic polyangiitis (MPA) is a systemic necrotizing vasculitis affecting small vessels.
- MPA can manifest in various organs, leading to diverse clinical presentations.
- Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, particularly anti-myeloperoxidase (anti-MPO) antibody disease, is a significant cause of renal and pulmonary involvement.
Observation:
- A 79-year-old man presented with constitutional symptoms, hematuria, elevated PSA, and acute kidney injury.
- Prostatic biopsy revealed vasculitic changes, initially raising suspicion for metastatic prostate cancer.
- Renal biopsy confirmed focal segmental necrotizing glomerulopathy with microscopic vasculitis.
Findings:
- The patient was diagnosed with anti-MPO antibody small-vessel vasculitis with prostatic and renal involvement.
- Positive perinuclear ANCA with anti-MPO antibodies and low C4 levels supported the diagnosis.
- Despite treatment with steroids and cyclophosphamide, the patient remained dialysis-dependent.
Implications:
- Prostatic vasculitis is an uncommon but significant manifestation of MPA.
- Early recognition and diagnosis of prostatic vasculitis are crucial for timely and effective treatment.
- This case underscores the importance of considering vasculitis in the differential diagnosis of unexplained prostatic and renal dysfunction.
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