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[Epidemiology of enterovirus associated with neurologic diseases]

Daniel M Cisterna1, Gustavo Palacios, Karina Rivero

  • 1Servicio de Neurovirosis, Instituto Nacional de Enfermedades Infecciosas ANLIS Dr. Carlos G. Malbrán, Buenos Aires. dcisterna@anlis.gov.ar

Medicina
|June 28, 2007
PubMed

Insights

Human enteroviruses (HEV) were detected in Argentinian patients with neurological diseases between 1991-1998. Echoviruses and Coxsackieviruses were common, particularly in children with meningitis and acute flaccid paralysis.

Area of Science:

  • Virology
  • Epidemiology
  • Neurology

Context:

  • Human enteroviruses (HEV) are a significant cause of neurological diseases globally.
  • Enterovirus surveillance is crucial for understanding disease burden and informing public health strategies.
  • Argentina has a history of enterovirus circulation, necessitating ongoing epidemiological studies.

Purpose:

  • To detect and characterize human enteroviruses (HEV) in patients with acute flaccid paralysis, aseptic meningitis, and acute encephalitis in Argentina.
  • To determine the prevalence of HEV in different neurological conditions and age groups.
  • To identify specific HEV serotypes associated with these diseases.

Summary:

  • HEV detection and characterization were performed using cell culture, PCR, and molecular typing on 2167 samples from 1991-1998.
  • HEV were isolated in 19.5% of cases; HEV RNA was detected in 28.8% of meningitis and 3.0% of encephalitis patients.
  • Children aged 1-9 years were most affected by meningitis, and 1-4 years by acute flaccid paralysis. Various Echovirus and Coxsackievirus serotypes were identified, with 28 serotypes found in acute flaccid paralysis cases.

Impact:

  • This study enhances the understanding of enterovirus epidemiology in Argentina and its link to neurological diseases.
  • The findings provide valuable data for future research and public health interventions.
  • Identified HEV serotypes can inform vaccine development and diagnostic strategies.

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