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Published on: January 28, 2020
[Detection of plasma level of placental growth factor from patients with coronary artery disease]
Gui-ying You1, Ye Zhu, Jian-ying Yu
1Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
Insights
Plasma placental growth factor (P1GF) is elevated in coronary artery disease (CAD) patients and correlates positively with lesion severity, aiding early diagnosis and risk assessment.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Clinical Chemistry
Background:
- Coronary artery disease (CAD) poses a significant global health burden.
- Accurate diagnostic and prognostic markers for CAD are crucial for patient management.
Purpose of the Study:
- To determine plasma placental growth factor (P1GF) levels in patients with CAD.
- To assess the correlation between plasma P1GF levels and the severity of coronary artery lesions.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma P1GF.
- Gensini coronary scoring system evaluated coronary lesion severity.
- Study included 48 CAD patients and 28 controls.
Main Results:
- Plasma P1GF levels were significantly higher in the CAD group (9.16±4.09 ng/L) compared to controls (3.64±1.90 ng/L) (P<0.01).
- A strong positive correlation (r=0.78, P<0.01) was observed between plasma P1GF levels and coronary lesion severity.
Conclusions:
- Plasma P1GF may serve as a valuable biomarker for the early diagnosis of CAD.
- P1GF levels can aid in evaluating the severity of coronary artery lesions.
Objective:
To investigate the plasma placental growth factor (P1GF) level of patients with coronary artery disease (CAD), and the correlation between plasma P1GF level and coronary lesion severity.
Methods:
The study population consisted of 48 patients with CAD (proved by angiography, CAD group) and 28 normal controls (control group). Plasma P1GF was determined by an enzyme linked immunosorbent assay (ELISA). The lesion severity of coronary artery was assessed by Gensini coronary scoring system, the correlation between plasma P1GF level and coronary lesion severity was evaluated.
Results:
The plasma PIGF level in CAD group was significantly higher than that in the control group C(9. 16+/-4. 09) ng/L vs (3. 64+/-1. 90) ng/L, P< 0. 01). A significant positive correlation was found between coronary lesion severity score and plasma P1GF level (r=0. 78, P<0. 01).
Conclusion:
The detection of plasma PIGF may be helpful to the early diagnosis of CAD and the evaluation of coronary lesion severity.
