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Flow of microgel capsules through topographically patterned microchannels.

Lindsey K Fiddes1, Edmond W K Young, Eugenia Kumacheva

  • 1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada.

Lab on a Chip
|June 28, 2007
PubMed
Summary

Microgel capsules in microfluidic devices showed altered flow dynamics through constrictions. Surface charge interactions significantly impacted microgel velocity changes, especially at specific orifice sizes and lower flow rates.

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Area of Science:

  • Fluid dynamics
  • Materials science
  • Biophysics

Background:

  • Microfluidic devices are crucial for manipulating small particles.
  • Understanding particle behavior in confined geometries is essential for various applications.
  • The interaction between charged particles and channel surfaces influences flow dynamics.

Purpose of the Study:

  • To investigate the flow dynamics of microgel capsules in patterned microfluidic channels.
  • To analyze the effects of confinement, surface interactions, and pre-passage velocity on microgel behavior.
  • To elucidate the role of electrostatic forces in microgel flow through orifices.

Main Methods:

  • Utilized topographically patterned microfluidic devices made of poly(dimethyl siloxane).
  • Studied negatively charged alginate microgels and positively charged alginate microgels coated with N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC).

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  • Drove microgel dispersions through microchannels and analyzed velocity changes at orifices under varying flow rates.

    • Main Results:

    • Microgel velocity increased when passing through orifices, with alginate microgels showing a larger increase than HTCC-coated microgels.
    • Electrostatic attraction/repulsion effects were strongest for orifices near the microgel diameter.
    • A 2x greater velocity increase was observed for alginate microgels in a 76 micrometer orifice compared to HTCC-coated microgels.
    • Lower initial flow rates amplified the velocity differences between microgel types.

    Conclusions:

    • Surface charge and microgel-orifice dimensions significantly influence microgel flow dynamics.
    • Electrostatic interactions play a critical role in modulating microgel velocity in microfluidic constrictions.
    • Findings provide insights for modeling the flow of biological suspensions like cells in microfluidic systems.