Optimized pH-responsive cyanine fluorochromes for detection of acidic environments
Scott A Hilderbrand1, Ralph Weissleder
1Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. Scott_Hilderbrand@hms.harvard.edu
Chemical Communications (Cambridge, England)
|June 28, 2007
Abstract:
Modulation of pH-responsive cyanine dye pK(a) values via heteroatom substitution allows for design of fluorescent reporters that are tuned for potential imaging of biologically relevant acidic environments.
