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["White dot syndromes" in childhood]

G Spital1, A Heiligenhaus, A Scheider

  • 1Augenabteilung am St.-Franziskus-Hospital Münster. gspital@arcor.de

Klinische Monatsblatter Fur Augenheilkunde
|June 28, 2007
PubMed

Insights

White dot syndromes are important in childhood uveitis diagnosis. These choriocapillaris inflammatory disorders require further study for incidence and management, with ICG angiography aiding diagnosis.

Area of Science:

  • Ophthalmology
  • Inflammatory Eye Diseases
  • Choriocapillaris Disorders

Context:

  • White dot syndromes represent a group of heterogeneous inflammatory disorders affecting the choriocapillaris.
  • Knowledge regarding their incidence and diagnostic relevance in pediatric uveitis remains limited.
  • These conditions were first described several decades ago.

Purpose:

  • To determine the incidence of various white dot syndromes in pediatric uveitis.
  • To review the literature for age predilections and characteristics of different white dot diseases.
  • To highlight the diagnostic importance of white dot syndromes in childhood uveitis.

Summary:

  • A retrospective analysis of 407 pediatric uveitis patients (1996-2006) identified acute posterior multifocal placoid pigment epitheliopathy (APMPPE), multiple evanescent white dot syndrome (MEWDS), multifocal choroiditis and panuveitis (MCP), and serpiginous choroiretinitis.
  • Literature review indicated varying age predilections for different white dot diseases.
  • The estimated relative frequency of white dot syndromes in pediatric uveitis is 1-5%.

Impact:

  • White dot syndromes are a crucial differential diagnosis for uveitis in children.
  • ICG angiography is essential for diagnosing and monitoring these inflammatory choriocapillaris diseases.
  • Different white dot syndromes exhibit distinct characteristics in incidence, prevalence, disease course, complications, and therapeutic approaches.
Abstract

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