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Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis

J Geddes1, K A Deans, A Cormack

  • 1Department of Diabetes, Glasgow Royal Infirmary, Glasgow, Scotland, UK.

Annals of Clinical Biochemistry
|June 28, 2007
PubMed

Insights

Minor elevations in cardiac troponin I (cTnI) occur in some adults with diabetic ketoacidosis (DKA). Further research is needed to understand the clinical significance of these findings in type 1 diabetes patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Elevated cardiac troponin I (cTnI) can occur in various conditions without ischemic heart disease.
  • The relationship between cTnI and diabetic ketoacidosis (DKA) in adults is not well-established.

Purpose of the Study:

  • To investigate the prospective relationship between serum cTnI and DKA in adult patients.
  • To determine the incidence and potential causes of elevated cTnI in DKA patients.

Main Methods:

  • Prospective study of 40 adult patients with type 1 diabetes and DKA.
  • Measurement of cTnI, creatine kinase, cystatin C, and beta-hydroxybutyrate on admission and up to 72 hours post-admission.
  • Daily electrocardiograms, echocardiography, and thallium-201 scintigraphy were performed.

Main Results:

  • Four out of 40 (10%) patients with DKA showed elevated cTnI levels.
  • In three patients, no obvious precipitating factors for elevated cTnI were identified.
  • Echocardiography and thallium-201 scintigraphy revealed no cardiac abnormalities in the affected cohort.

Conclusions:

  • Minor troponin elevations are observed in a small subset of type 1 diabetes patients presenting with DKA.
  • The clinical relevance of these troponin elevations in DKA remains uncertain.
  • Larger-scale studies are recommended to further elucidate the significance of these findings.
Abstract

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